Topical Application of Imiquimod as a Treatment for Chromoblastomycosis
نویسندگان
چکیده
Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.
منابع مشابه
Treatment of infantile hemangioma with topical imiquimod 5% cream
Background: Infantile hemangioma is a congenital vascularmalformation. Although almost all cases are self-limiting, treatmentis sometimes necessary. According to previous studies, topicalimiquimod induces resolution of lesions with an acceptable safetyprofile. The aim of the present study was to evaluate the effect ofthis topical treatment on Iranian infantile hemangioma patients.Method: Patien...
متن کاملTreatment of recurrent genital Herpes with Imiquimod: A case report
In this report, a 32 year-old patient is reported who was suffering from recurrent genital herpes for 3 years and her disease could not be controlled with conventional treatment methods. But, application of Imiquimod 5% cream, 3 times a week for 3 months, proved very effective with no recurrence for up to 7 months. Since recurrent genital herpes is the result of some immunologic dysfunctions ca...
متن کاملEfficacy of topical 5% imiquimod with cryotherapy versus intralesional meglumine antimoniate in the treatment of anthroponotic cutaneous leishmaniasis
Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy vs. intralesional meglumine antimoniate (MA) in treatment of anthroponotic (dry type) CL. ...
متن کاملMelanoma Arising after Imiquimod Use
Imiquimod belongs to the class of 1H-imidazo-[4,5-c]quinolones-drugs originally developed as nucleoside analogues with the aim of finding new potential antiviral agents (Harrison et al., 1988). Indeed, Imiquimod was first released as treatment for genital warts before its actions against skin cancer were studied. Imiquimod is a relatively small sized molecule (Mr = 240.3) and is hydrophobic, al...
متن کاملTreatment of Keratoacanthoma with 5% Imiquimod Cream and Review of the Previous Report
Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surgery is considered the treatment of choice. Recently, regression of KAs following application of 5% imiquimod cream (Aldara®) has been reported. We ...
متن کامل